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Make the Diagnosis |
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Dr. Donna Bilu Martin is a board-certified dermatologist in private practice in Miami, specializing in cosmetic, medical, and surgical dermatology. She coauthored a published chapter in the 2008 textbook "Clinical and Basic Immunodermatology: Clinical Diagnosis and Management" (Springer, 2008) and numerous articles that have appeared in a variety of medical and dermatologic journals. Her work has been presented at national dermatology conferences. Dr. Bilu Martin is a volunteer instructor of dermatology at the Miller School of Medicine at the University of Miami. |
Diagnosis: Axillary Granular Parakeratosis
A biopsy was performed and revealed retention of keratohyaline granules in areas of parakeratosis in the stratum corneum. The patient was treated with daily topical tretinoin cream with improvement in the lesions after 6 weeks.
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Axillary granular parakeratosis is a benign condition with an unclear etiology. It may be a disorder of keratinization due to a defect in the processing of profilaggrin to filaggrin.
Use of personal hygiene products, an occlusive environment, increased sweating, and local irritation could also play a role but a causal link has not been proven.
Granular parakeratosis can present in any intertriginous fold, although axillae are most commonly affected. It is mostly reported in women aged 40-50 years, and there is no racial predilection.
The differential diagnosis includes acanthosis nigricans, causes of intertrigo (seborrheic dermatitis, candidiasis, inverse psoriasis, inverse lichen planus, and erythrasma), Hailey-Hailey disease, Darier's disease, pemphigus vegetans, and irritant or contact dermatitis. A biopsy revealed the diagnosis.
Treatments aim to control the pruritus and reduce lesions and include topical corticosteroids, oral and topical retinoids, topical calcipotriene, and ammonium lactate. Minimizing the use of irritating personal care products and occlusion may improve the condition, as well.
What’s your diagnosis? |
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| Hailey-Hailey disease | 17.7% | ||
| Darier’s disease | 8.8% | ||
| Axillary granular parakeratosis | 73.5% | ||
Aexis Manrique from Venezuela
Thursday, 06/23/11 08:04
Entidad poco frecuente o poco pensada. Buen resultado con rerinoides topicos pero recidiva frecuente.
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I am a: |
| May 19 - 22 Sao Paulo, | XXX RADLA 2012: Annual Meeting of Latin American Dermatologists |
| May 20 - 23 Brisbane, | Australasian College of Dermatologists: Annual Scientific Meeting |
| May 24 - 27 Chandler, AZ | American Society for MOHS Surgery (ASMS): Annual Dermatologic Surgery Clinical Symposium |
| May 25 - 28 Orlando, FL | Florida Society of Dermatology & Dermatologic Surgery (FSDDS): Annual Meeting |
| Jun 1 - 3 Hilton Head Island, SC | Georgia Society of Dermatologists (GSD): Annual Meeting |
| Jun 1 - 3 Dana Point, CA | Summit in Aesthetic Medicine 2012 |
| Jun 6 - 10 Verona, | European Academy of Dermatology and Venereology (EADV): Spring Symposium |
| Jun 7 - 8 New York, NY | New York University (NYU): Advances in Dermatology |
| Jun 12 - 16 Malmo, | European Society of Contact Dermatitis (ESCD): 11th Congress |
| Jun 15 Albany, NY | Albany Medical College: Annual Dermatology Teaching Day |
Seminars In Cutaneous Medicine And Surgery
Seminars in Cutaneous Medicine and Surgery publishes topical reviews that address critical advances in the practice of medical and surgical dermatology. In-depth coverage of topics integral to the specialty, includes dermatologic surgery, general dermatology and dermatopathology.March 2012 - Updates in Medical Dermatology
June 2012 - Frontiers in Dermatologic Surgery
September 2012 - eDermatology
December 2012 - Molecular Dermatology and Pathology
More Seminars »
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